1.Medical Prescript on anatoxins bacterial product...

1.PRESCRIPT

on anatoxins vaccine usage to prevent

streptococcusis of farm, carnivorous and gnawing animals and of avifauna.

STREPTOEVAK

1.General Terms

1.1. Anatoxins vaccine against streptococcusis among farm, carnivorous and gnawing animals as well as avifauna has been produced of streptococcus germ culture belonging to serogroup С inactivated in formaline and deposited in aluminum hydroxine.

1.2.In outward appearance it is a coarse dispersion of yellowish-grey color with batting residual matter which is forming at the bottom of bottle when stored and such sedimentation easily restores its homogenous condition when shaking the bottle.

1.3.As a biopharmaceutical product this vaccine appears on the market measured out in doses of 0.5, 1.0, 2.0, 3.0, 50 and 200 ml. The bottle of anatoxins vaccine should be hermetically sealed with rubber cork aluminum rolled capping. Each bottle must be labeled and provide the following information, namely: denomination of the manufacture and its trade mark, name of vaccine, the quantity of vaccine in the bottle (in ml), number of series, control number, manufacturing date (month and year), expiration date, storing conditions, specifications and cautionary warning For Animal Beings Only.

1.4. The bottle which does not carry any labeling or marking, and/or contains mold, extraneous bodies, flakes which remain even when shaking the bottle, having broken or defective capping as well as remaining anatoxins vaccine which was opened and not used within the same day should be rejected. The vaccine is normally destructed by boiling it within 10 minutes.

1.5. Anatoxins vaccine is suitable for usage within the two years from the date of manufacturing subject it is stored in a dry dark place under the temperatures of environment from 2 to 100 degrees Centigrade.

2. Biological Properties

2.1. Anatoxins vaccine ensures active imunity of vaccinated animals against streptococcusis. Anatoxins vaccine is quite safe and arectogenious.

2.2. Vaccinated animal beings start having such imunity after 11-13 days following the first injection of this vaccine and remain immune over the next 6 months and longer.

2.3. Anatoxins vaccine has also a curative effect when streptococcusis afflicts farm, carnivorous and gnawing animals and avifauna fighting such diseases as blue bag, endometritis, cystitis, nefritis, eye mucositis, ear auricle inflammation, arthritis, gastric and intestinal mucosa, respiratory organ diseases, derma inflations and abscesses, as well as reduces surgical complications. Anatoxins vaccine neutralizes immunologic attack of own body’s tissue, affected by pathogetic streptococcus.

2.4. Anatoxins vaccine neutralizes exotoxin of biological agent and prevents tissue injury and damage.

2.5. Anatoxins vaccine is an immunostimulant of immune-evocation which generates polyclonal agitation B- поликлональной активации В – lymphocytes and normalize equilibrium in sub-components of T-lymphoid cells.

3. Vaccine Treatment Prescription

3.1. Anatoxins vaccine is used to provide immunity to farm, carnivorous and gnawing animals as well as avifauna in the farms and animal retainers where there is a risk of streptococcus disease.

3.2. Male and female animals are being vaccinated between 30 and 50 days prior service for breeding. Springer cows are being vaccinated twice 50-60 days prior calving with the doses 2.0 and 3.0 ml the interval between the vaccinations being from 10 to 14 days. Stud bulls get vaccinated between 30 and 50 days prior service for breeding with the same doses. Calves are vaccinated when they reach 18-21 days of life with the doses of 2.0 and 3.0 ml and the interval between the vaccinations should be from 10 to 14 days.

3.3.Breeding sows are being vaccinated within the period of 30 and 50 days prior farrowing with the doses of 2.0 and 3.0 ml the interval between the vaccinations being from 10 to 14 days. Male pigs get vaccinated between 30 and 50 days prior service for breeding with the same doses. Young pigs are vaccinated twice prior breaking into milk with the doses of 0.5 and 1.0 ml the interval between the vaccinations being from 10 to 14 days.

3.4.Fur animals, gnawers, dogs and cats (male and female) are vaccinated 20-30 days before service, growing stock – twice after breaking into milk with the following doses: the weight of animal being less than 5 kgs – 0.3 and 0.5 ml, over 5 kgs respectively 0.5 and 1.5 ml and over 35 kgs – 1.0 and 1.5 ml and the interval between the vaccinations being from 10 to 14 days.

3.5. Household and fancy poultry is vaccinated starting from 2 months of age when under 3 kgs of weight with the dose: 0.2 and 0.3ml, and over 3 kgs of weight with the doses of 0.3 and 0.5 ml.

3.6.For treatment purposes the doses of this biological product should be increased in 2 or 3 times and used in accordance with the prescription. The third dose is normally injected following one month after the the first one and the forth dose – after 2 months following the first injection.

3.7.Every bottle of Anatoxins vaccine should be shaked well before usage to get a homogeneous substance. In a very cold environment it ie required to warm the bottle with vaccine on steam up to the temperature of 30-36 degrees Centigrades.

3.8. Anatoxins vaccine injection is made intramuscularly to a hip zone, which has to be previously desinfected, syringe and needles should be asepticized in boling water for 10 minutes. At the point of injection a small concretion may appear which will resolve in 3-5 days after vaccination.

4. Claiming Procedures

4.1. In case of complications after vaccination or non-effectiveness the usage of products of the same series should be stopped and in accordance with the instructions of Head Veterinary Department on claiming procedures dated 19/09/1987 such cases should be reported to the All-Union State Science and Research Institute for veterinary medicines standards and certifications (5, Zvenigorodskoie shosse, Moscow, 123022). At the same time two bottles of vaccine as minimum should be sent to the institute of those which caused such complications. The duplicate of the letter should be sent to the manufacturer.

Vaccine having its term expired should not be accepted.


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