[Cancer Research 34, 932-937, May 1, 1974]
© 1974 American Association for Cancer Research
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Articles by Collins, J. L.
Articles by Wust, C. J.

Suppression of SV40 Tumors after Immunization with Group A Streptococcus pyogenes and Bordetella pertussis1
John L. Collins2 and Carl J. Wust
Department of Microbiology, University of Tennessee, Knoxville, Tennessee 37916


Tumors produced by a line of SV40-transformed cells in golden Syrian hamsters were suppressed in 60% of animals immunized with a mixed vaccine of Group A Streptococcus pyogenes and Bordetella pertussis. There was a suppression of tumor growth in 50% of animals immunized with S. pyogenes vaccine alone. Polysaccharides were extracted from S. pyogenes and tumor cells by an identical procedure. Antibody titers to these polysaccharides were measured and were found to be depressed in both tumor-bearing and suppressed animals during the period when tumors were rapidly growing in tumor-bearing animals. Antibody to tumor polysaccharide reacted with tumor and S. pyogenes polysaccharides. Such antibody was found in sera and also could be eluted from tumors. The ligands, N-acetyl-D-glucosamine and L-rhamnose, which are the major constituents of the cell wall of S. pyogenes, did not bind with any serum. There was a significantly lower level of sialoglycoprotein in the sera of tumor-bearing animals than was found in that of control animals.

1 Aided by Grant IN-89D from the American Cancer Society.

2 Predoctoral Trainee, NIH Training Grant T01-AI00435.

Received 8/ 3/73. Accepted 1/21/74.




http://cancerres.aacrjournals.org/cgi/content/abstract/34/5/932